Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL 		0.700 Biomarker disease GENOMICS_ENGLAND Germline genetic profiling in prostate cancer: latest developments and potential clinical applications. 28031937 2016
Entrez Id: 60528
Gene Symbol: ELAC2
ELAC2 		0.600 Biomarker disease GENOMICS_ENGLAND Germline genetic profiling in prostate cancer: latest developments and potential clinical applications. 28031937 2016
Entrez Id: 4481
Gene Symbol: MSR1
MSR1 		0.580 Biomarker disease GENOMICS_ENGLAND Germline genetic profiling in prostate cancer: latest developments and potential clinical applications. 28031937 2016
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL 		0.700 SusceptibilityMutation disease ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
Entrez Id: 60528
Gene Symbol: ELAC2
ELAC2 		0.600 SusceptibilityMutation disease ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13 		0.600 SusceptibilityMutation disease ORPHANET The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. 22236224 2012
Entrez Id: 4481
Gene Symbol: MSR1
MSR1 		0.580 SusceptibilityMutation disease ORPHANET Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. 12244320 2002
Entrez Id: 4481
Gene Symbol: MSR1
MSR1 		0.580 SusceptibilityMutation disease ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.520 SusceptibilityMutation disease ORPHANET Additional screening for CHEK2 mutations in 149 families with familial prostate cancer revealed 11 mutations (5 unique) in nine families. 12533788 2003
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.380 SusceptibilityMutation disease ORPHANET Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer. 17700570 2007
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.360 SusceptibilityMutation disease ORPHANET Prostate cancer: germline prediction for a commonly variable malignancy. 22974436 2012
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.360 SusceptibilityMutation disease ORPHANET Cancer Incidence in BRCA1 mutation carriers. 12237281 2002
Entrez Id: 4477
Gene Symbol: MSMB
MSMB 		0.320 SusceptibilityMutation disease ORPHANET Mutation analysis of the MSMB gene in familial prostate cancer. 19997100 2010
Entrez Id: 4477
Gene Symbol: MSMB
MSMB 		0.320 SusceptibilityMutation disease ORPHANET Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. 19383797 2009
Entrez Id: 4477
Gene Symbol: MSMB
MSMB 		0.320 SusceptibilityMutation disease ORPHANET Multiple newly identified loci associated with prostate cancer susceptibility. 18264097 2008
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2 		0.310 GeneticVariation disease ORPHANET
Entrez Id: 4683
Gene Symbol: NBN
NBN 		0.310 SusceptibilityMutation disease ORPHANET NBS1 is a prostate cancer susceptibility gene. 14973119 2004
Entrez Id: 4683
Gene Symbol: NBN
NBN 		0.310 SusceptibilityMutation disease ORPHANET In this study, 94 unrelated familial prostate cancer cases from the University of Michigan Prostate Cancer Genetics Project (n = 54) and Johns Hopkins University (n = 40) were subjected to targeted next-generation sequencing of the exons, including UTRs, of NBN. 22864661 2012
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2 		0.310 SusceptibilityMutation disease ORPHANET A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. 16155194 2006
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.300 SusceptibilityMutation disease ORPHANET Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. 18701471 2008
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL 		0.700 Biomarker disease CTD_human
Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13 		0.600 Biomarker disease CTD_human The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. 22236224 2012
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.520 Biomarker disease CTD_human Additional screening for CHEK2 mutations in 149 families with familial prostate cancer revealed 11 mutations (5 unique) in nine families. 12533788 2003
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.330 Biomarker disease CTD_human Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.310 Biomarker disease CTD_human Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP. 16189707 2005